Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation targeting an underground arms cache in Syria operated by the IS group, per a report from the UK's MoD.
The location, pinpointed through reconnaissance, was thought to be containing munitions and bombs, the release indicated, and was located in mountainous terrain just north of Palmyra in Syria's central region.
"The RAF jets employed precision-guided Paveway IV munitions to hit a series of entry passages leading to the site... initial indications suggest the strike was effective," the ministry announced.
There was no evidence of any harm to civilians in the operation late on Saturday and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - enforced jihadist rule over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and commitment to operate in unison with allied nations, to eradicate any resurgence of the terrorist group and their violent and radical beliefs in the area," Britain's Defence Chief the Defence Secretary remarked.
UK warplanes have conducted surveillance missions over Syria to "forestall any attempted comeback" of IS subsequent to its defeat at the Baghuz confrontation in the year 2019, the authorities noted.
"I must thank the personnel of British forces who took part in this operation for their skill and their courage," the Defence Secretary said. "They were part of numerous British personnel on duty over Christmas and New Year. This action, to take out militants who pose a risk to our security, demonstrates how British military are prepared to act, continuously, ensuring Britain's security domestically and influential overseas."
In December, the American forces carried out what it described as a "major assault" on Islamic State objectives in the country, following an ambush claimed the lives of two US troops and a civilian linguist in Palmyra.
The U.N. says Islamic State still boasts an estimated 5,000 to 7,000 militants in Iraq and Syria.